Moving in stead of asking? Performance-based tests and BASFI-questionnaire measure different aspects of physical function in Ankylosing Spondylitis. (Arthritis Research & Therapy)

IntroductionAnkylosing Spondylitis (AS) is characterised by limitations in physical function. The Bath Ankylosing Spondylitis Functional Index (BASFI) is considered to be the gold-standard to assess physical function in AS patients. However, the BASFI-questionnaire is a self-reported outcome measure and susceptible to subjective interpretation (under- or over-estimation). More objective outcome measures, like performance-based tests, could provide an objective outcome measurement for the evaluation of limitations in physical function. Therefore, the primary aim of this study was to determine the association between performance-based measures and the BASFI-questionnaire. Methods: In this cross-sectional study 126 AS patients completed the BASFI-questionnaire and eight performance-based tests based on BASFI-items. Each test received three scores: one for performance (time or points) and a score for exertion and pain experienced during performance (using modified Borg-scale and VAS 0-100 mm, respectively). Linear regression analyses were used to assess the associations between the BASFI-questionnaire and performance-based tests. Results: The univariable association between performance and BASFI-score was moderate with a R-square of 0.31 and Beta of 0.56 (p`s < 0.05). In a multivariable analysis, the association between performance, exertion and pain on the one hand and BASFI-score on the other was assessed; R-square increased to 0.54: the Beta`s for exertion and pain during performance were 0.38 and 0.26, respectively; the Beta for performance decreased to 0.19 (p`s < 0.05). Conclusions: This study demonstrates that alongside actual performance, patients seem to incorporate exertion and pain in their assessment of perceived physical function on the BASFI-questionnaire. Performance-based tests could provide an objective outcome measurement for the evaluation of physical function and give relevant new information in addition to the BASFI-questionnaire.