MyJournals Home  

RSS FeedsInterval colon cancer in a Lynch syndrome patient under annual colonoscopic surveillance: a case for advanced imaging techniques? (BMC Gastroenterology)

 
 

24 may 2012 12:16:27

 
Interval colon cancer in a Lynch syndrome patient under annual colonoscopic surveillance: a case for advanced imaging techniques? (BMC Gastroenterology)
 


Background: Lynch syndrome confers increased risk for various malignancies, including colorectal cancer.Colonoscopic surveillance programs have led to reduced incidence of colorectal cancer andreduced mortality from colorectal cancer. Colonoscopy every 1-2 years beginning at age 20-25, or 10 years earlier than the first diagnosis of colorectal cancer in a family, with annualcolonoscopy after age 40, is the recommended management for mutation carriers. Screeningprograms have reduced colon cancer mortality, but interval cancers may occur.Case presentationWe describe a 48-year-old woman with Lynch syndrome who was found to have an adenomawith invasive colorectal cancer within one year after a normal colonoscopy. Conclusion: Our patient illustrates two current concepts about Lynch syndrome: 1) adenomas are thecancer precursor and 2) such adenomas may be `aggressive,` in the sense that the adenomaprogresses more readily and more rapidly to carcinoma in this setting compared to usualcolorectal adenomas. Our patient`s resected tumor invaded only into submucosa and alllymph nodes were negative; in that sense, she represents a success for annual colonoscopicsurveillance. Still, this case does raise the question of whether advanced imaging techniquesare advisable for surveillance colonoscopy in these high-risk patients.


 
177 viewsCategory: Pathology
 
Kruppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency (Orphanet Journal of Rare Diseases)
The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis (BMC Gastroenterology)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Pathology


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten