MyJournals Home  

RSS FeedsComputational genetics analysis of grey matter density in Alzheimer¿s disease (BioData Mining)

 
 

26 august 2014 18:22:05

 
Computational genetics analysis of grey matter density in Alzheimer¿s disease (BioData Mining)
 


Background: Alzheimer`s disease is the most common form of progressive dementia and there is currently no known cure. The cause of onset is not fully understood but genetic factors are expected to play a significant role. We present here a bioinformatics approach to the genetic analysis of grey matter density as an endophenotype for late onset Alzheimer`s disease. Our approach combines machine learning analysis of gene-gene interactions with large-scale functional genomics data for assessing biological relationships. Results: We found a statistically significant synergistic interaction among two SNPs located in the intergenic region of an olfactory gene cluster. This model did not replicate in an independent dataset. However, genes in this region have high-confidence biological relationships and are consistent with previous findings implicating sensory processes in Alzheimer`s disease. Conclusions: Previous genetic studies of Alzheimer`s disease have revealed only a small portion of the overall variability due to DNA sequence differences. Some of this missing heritability is likely due to complex gene-gene and gene-environment interactions. We have introduced here a novel bioinformatics analysis pipeline that embraces the complexity of the genetic architecture of Alzheimer`s disease while at the same time harnessing the power of functional genomics. These findings represent novel hypotheses about the genetic basis of this complex disease and provide open-access methods that others can use in their own studies.


 
312 viewsCategory: Bioinformatics
 
ECCB 2014 Organization (Bioinformatics)
MendeLIMS: a web-based laboratory information management system for clinical genome sequencing (BMC Bioinformatics)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Bioinformatics


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten