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RSS FeedsA novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice (BMC Genomics)

 
 

24 november 2014 04:15:25

 
A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice (BMC Genomics)
 


Background: Genetic variation in the human population is a key determinant of influenza disease severity. A single nucleotide polymorphism in the antiviral gene IFITM3 was linked to outcomes during the 2009 H1N1 pandemic. To identify variant host genes associated with increased virus replication and severe disease, we performed a quantitative trait locus analysis on pro-inflammatory cytokine production 48 hours after intranasal infection with highly pathogenic H5N1 influenza virus. Results: Pro-inflammatory cytokines CCL2, TNFalpha and IFN-alpha, were measured by ELISA in lung homogenates of DBA/2J (D2), C57BL/6J (B6) and 44 different BXD recombinant inbred mouse strains. Virus titer was also assessed in a subset of these animals. CCL2 (8-fold), TNFalpha (24-fold) and IFN-alpha (8-fold) concentrations varied significantly among the different BXD RI strains. Importantly, cytokine concentration correlated very well (r =0.86-0.96, P


 
173 viewsCategory: Genomics
 
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