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RSS FeedsEffects of treatment with Astragalus Membranaceus on function of rat leydig cells (BMC Complementary and Alternative Medicine)

 
 

1 august 2015 13:35:02

 
Effects of treatment with Astragalus Membranaceus on function of rat leydig cells (BMC Complementary and Alternative Medicine)
 


Background: Astragalus membranaceus (AM) is a Chinese traditional herb which has been reported to have broad positive effects on many diseases, including hepatitis, heart disease, diabetes and skin disease. AM can promote cell proliferation, increase the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx), and inhibit apoptosis by regulating the transcription of proto-oncogenes controlling cell death. While AM is included in some commercially available “testosterone boosting supplements”, studies directly testing ability of AM to modulate testosterone production are lacking. In the present study, we examined the effects of AM on Leydig cell function in vitro. Methods: Rat Leydig cells were purified and treated with AM at different concentrations (0 μg/mL, 10 μg/mL, 20 μg/mL, 50 μg/mL, 100 μg/mL and 150 μg/mL) and cell counting-8 (CCK-8) assay, Enzyme-linked immunosorbent assay, quantitative real time PCR and analysis of activities of SOD and GPx were done respectively. Results: Treatment with 100 μg/mL (P 


 
152 viewsCategory: Medicine
 
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