Immunology: T-cell exhaustion limits immune reactivity and is associated with good prognosis in autoimmune disease (Nature Clinical Practice Rheumatology)

A transcriptional signature of CD8 T-cell exhaustion is associated with good prognosis in multiple autoimmune diseases--including anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and systemic lupus erythematosus (SLE)--but with poor outcomes in chronic infections, say researchers Eoin McKinney and colleagues. They suggest that measuring this signature could