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RSS FeedsMolecules, Vol. 21, Pages 678: Structure Identification and Anti-Cancer Pharmacological Prediction of Triterpenes from Ganoderma lucidum (Molecules)

 
 

21 may 2016 12:47:11

 
Molecules, Vol. 21, Pages 678: Structure Identification and Anti-Cancer Pharmacological Prediction of Triterpenes from Ganoderma lucidum (Molecules)
 


Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. In the present study, systematic isolation, and in silico pharmacological prediction are implemented to discover potential anti-cancer active GTs from G. lucidum. Nineteen GTs, three steroids, one cerebroside, and one thymidine were isolated from G. lucidum. Six GTs were first isolated from the fruiting bodies of G. lucidum, including 3?,7?,15?-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl ester (1), 3?,7?,15?-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (2), 3?,7?,15?,28-tetrahydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (3), ganotropic acid (4), 26-nor-11,23-dioxo-5?-lanost-8-en-3?,7?,15?,25-tetrol (5) and (3?,7?)-dihydroxy-lanosta-8,24-dien- 11-one (6). (4E,8E)-N-d-2´-hydroxypalmitoyl-l-O-?-d-glucopyranosyl-9-methyl-4,8-spingodienine (7), and stigmasta-7,22-dien-3?,5?,6?-triol (8) were first reported from the genus Ganodema. By using reverse pharmacophoric profiling of the six GTs, thirty potential anti-cancer therapeutic targets were identified and utilized to construct their ingredient-target interaction network. Then nineteen high frequency targets of GTs were selected from thirty potential targets to construct a protein interaction network (PIN). In order to cluster the pharmacological activity of GTs, twelve function modules were identified by molecular complex detection (MCODE) and gene ontology (GO) enrichment analysis. The results indicated that anti-cancer effect of GTs might be related to histone acetylation and interphase of mitotic cell cycle by regulating general control non-derepressible 5 (GCN5) and cyclin-dependent kinase-2 (CDK2), respectively. This research mode of extraction, isolation, pharmacological prediction, and PIN analysis might be beneficial to rapidly predict and discover pharmacological activities of novel compounds.


 
169 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
Molecules, Vol. 21, Pages 675: Astragalin, a Flavonoid from Morus alba (Mulberry) Increases Endogenous Estrogen and Progesterone by Inhibiting Ovarian Granulosa Cell Apoptosis in an Aged Rat Model of Menopause (Molecules)
Molecules, Vol. 21, Pages 677: Synthesis and p38 Inhibitory Activity of Some Novel Substituted N,N´-Diarylurea Derivatives (Molecules)
 
 
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