[Review] Metal-catalyzed reductive coupling of olefin-derived nucleophiles: Reinventing carbonyl addition (Science)

?-Olefins are the most abundant petrochemical feedstock beyond alkanes, yet their use in commodity chemical manufacture is largely focused on polymerization and hydroformylation. The development of byproduct-free catalytic C-C bond-forming reactions that convert olefins to value-added products remains an important objective. Here, we review catalytic intermolecular reductive couplings of unactivated and activated olefin-derived nucleophiles with carbonyl partners. These processes represent an alternative to the longstanding use of stoichiometric organometallic reagents in carbonyl addition. Authors: Khoa D. Nguyen, Boyoung Y. Park, Tom Luong, Hiroki Sato, Victoria J. Garza, Michael J. Krische