Autoimmunity: HLA-mediated protection in Goodpasture disease (Nature Clinical Practice Rheumatology)

A new study provides insights into the molecular mechanisms of HLA-mediated susceptibility and protection in Goodpasture disease (GPD). This rare renal disorder is characterized by autoimmune responses to the non-collagenous domain of the α3 chain of type IV collagen (α3(IV)NC1). Expression of HLA-DR15 is associated