MyJournals Home  

RSS FeedsIJMS, Vol. 18, Pages 1596: Autophagy and Human Neurodegenerative Diseases--A Fly`s Perspective (International Journal of Molecular Sciences)

 
 

23 july 2017 13:46:03

 
IJMS, Vol. 18, Pages 1596: Autophagy and Human Neurodegenerative Diseases--A Fly`s Perspective (International Journal of Molecular Sciences)
 


Neurodegenerative diseases in humans are frequently associated with prominent accumulation of toxic protein inclusions and defective organelles. Autophagy is a process of bulk lysosomal degradation that eliminates these harmful substances and maintains the subcellular environmental quality. In support of autophagy`s importance in neuronal homeostasis, several genetic mutations that interfere with autophagic processes were found to be associated with familial neurodegenerative disorders. In addition, genetic mutations in autophagy-regulating genes provoked neurodegenerative phenotypes in animal models. The Drosophila model significantly contributed to these recent developments, which led to the theory that autophagy dysregulation is one of the major underlying causes of human neurodegenerative disorders. In the current review, we discuss how studies using Drosophila enhanced our understanding of the relationship between autophagy and neurodegenerative processes.


 
116 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 18, Pages 1597: Application of Extrusion-Based Hydrogel Bioprinting for Cartilage Tissue Engineering (International Journal of Molecular Sciences)
IJMS, Vol. 18, Pages 1598: An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity (International Journal of Molecular Sciences)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Molecular Biology


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten