MyJournals Home  

RSS FeedsToxins, Vol. 9, Pages 232: The Putative Histone Methyltransferase DOT1 Regulates Aflatoxin and Pathogenicity Attributes in Aspergillus flavus (Toxins)

 
 

24 july 2017 17:00:05

 
Toxins, Vol. 9, Pages 232: The Putative Histone Methyltransferase DOT1 Regulates Aflatoxin and Pathogenicity Attributes in Aspergillus flavus (Toxins)
 


Lysine methyltransferases transfer methyl groups in specific lysine sites, which regulates a variety of important biological processes in eukaryotes. In this study, we characterized a novel homolog of the yeast methyltransferase DOT1 in A. flavus, and observed the roles of dot1 in A. flavus. Deletion of dot1 showed a significant decrease in conidiation, but an increase in sclerotia formation. A change in viability to multiple stresses was also found in the ?dot1 mutant. Additionally, aflatoxin (AF) production was found severely impaired in the ?dot1 mutant. Further analysis by qRT-PCR revealed that the transcription of AF structural genes and their regulator gene aflS were prominently suppressed in the ?dot1 mutant. Furthermore, our data revealed that Dot1 is important for colonizing maize seeds in A. flavus. Our research indicates that Dot1 is involved in fungal development, aflatoxin biosynthesis and fungal virulence in A. flavus, which might provide a potential target for controlling A. flavus with new strategies.


 
99 viewsCategory: Toxicology
 
Toxins, Vol. 9, Pages 231: Microcystin Prevalence throughout Lentic Waterbodies in Coastal Southern California (Toxins)
Toxins, Vol. 9, Pages 233: Different Metabolic Pathways Are Involved in Response of Saccharomyces cerevisiae to L-A and M Viruses (Toxins)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Toxicology


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten