Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy (Cell Reports)

Sleep disorders are common in neurodevelopmental disorders such as the tuberous sclerosis complex (TSC). Lipton et al. demonstrate that increased translation and decreased degradation of the core clock protein BMAL1 underlie circadian rhythm abnormalities in TSC mouse and cellular models.