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RSS FeedsA type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells (BMC Cancer)

 
 

11 august 2017 22:18:01

 
A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells (BMC Cancer)
 




Mutations of the DNA repair proteins BRCA1/2 are synthetically lethal with the DNA repair enzyme poly(ADP-ribose) polymerase (PARP), which when inhibited, leads to cell death due to the absence of compensatory...


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100 viewsCategory: Oncology
 
Association of long non-coding RNA H19 and microRNA-21 expression with the biological features and prognosis of non-small cell lung cancer (Cancer Gene Therapy)
Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth (Oncogene)
 
 
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