Polycystic kidney disease: SMYD2 is a novel epigenetic regulator of cyst growth (Nature Clinical Practice Nephrology)

Autosomal dominant polycystic kidney disease (ADPKD), which is caused by mutations in PKD1 and PKD2, is the most common inherited kidney disease, but no FDA-approved treatment currently exists. In a new study, Xiaogang Li and colleagues report that the methyltransferase SMYD2 is an