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RSS FeedsMolecules, Vol. 22, Pages 1562: Cytotoxic and Hypoglycemic Activity of Triterpenoid Saponins from Camellia oleifera Abel. Seed Pomace (Molecules)

 
 

21 september 2017 11:17:18

 
Molecules, Vol. 22, Pages 1562: Cytotoxic and Hypoglycemic Activity of Triterpenoid Saponins from Camellia oleifera Abel. Seed Pomace (Molecules)
 


One new and three known triterpenoid saponins were isolated and identified from Camellia oleifera seeds through IR, NMR, HR-ESI-MS and GC-MS spectroscopic methods, namely oleiferasaponin A3, oleiferasaponin A1, camelliasaponin B1, and camelliasaponin B2. The structure of oleiferasaponin A3 was elucidated as 16?-hydroxy-21?-O-angeloyl-22?-O-cinnamoyl-23?-aldehyde-28-dihydroxymethylene-olean-12-ene-3?-O-[?-d-galactopyranosyl-(1->2)]-[?-d-xylopyranosyl-(1->2)-?-d-galactopyranosyl-(1->3)]-?-d-gluco-pyranosiduronic acid. Camelliasaponin B1 and camelliasaponin B2 exhibited potent cytotoxic activity on three human tumour cell lines (human lung tumour cells (A549), human liver tumour cells (HepG2), cervical tumour cells (Hela)). The hypoglycemic activity of oleiferasaponin A1 was testified by protecting pancreatic ?-cell lines from high-glucose damage.


 
122 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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