Divergent JNK Phosphorylation of HDAC3 in Triple-Negative Breast Cancer Cells Determines HDAC Inhibitor Binding and Selectivity (Cell Chemical Biology)

Hanigan et al. developed a method to identify relevant HDAC isoforms associated with inhibitor efficacy in breast cancer cells. They found c-Jun N-terminal kinase phosphorylation increases inhibitor binding and selectivity, and causes divergent regulation of HDAC3 in triple-negative versus luminal cells.