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RSS FeedsIJMS, Vol. 18, Pages 2118: Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice (International Journal of Molecular Sciences)

 
 

10 october 2017 12:46:17

 
IJMS, Vol. 18, Pages 2118: Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice (International Journal of Molecular Sciences)
 




Chronic ultraviolet (UV) exposure may cause skin damage, disrupt skin barrier function, and promote wrinkle formation. UV induces oxidative stress and inflammation, which results in extracellular matrix degradation in the dermis and epidermal hyperplasia. Our previous study demonstrated that fisetin exerts photoprotective activity by inhibiting mitogen-activated protein kinase/activator protein-1/matrix metalloproteinases (MMPs) activation. In this study, fisetin was applied topically to investigate its antiphotodamage effects in hairless mice. The erythema index (a* values) and transepidermal water loss were evaluated to assess skin damage, and immunohistochemical staining was conducted to elucidate the photoprotective mechanism of fisetin. The results revealed that the topical application of fisetin reduced UVB-induced increase in the a* value and wrinkle formation. In addition, fisetin inhibited epidermal hyperplasia and increased the collagen content in the dermis. Fisetin exerted photoprotective activity by inhibiting the expression of MMP-1, MMP-2, and cyclooxygenase-2 and increasing the expression of nuclear factor erythroid 2-related factor. Furthermore, fisetin increased the expression of filaggrin to prevent UVB-induced barrier function disruption. Altogether, the present results provide evidence of the effects and mechanisms of fisetin`s antiphotodamage and antiphotoinflammation activities.


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86 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 18, Pages 2113: Addendum: Palmieri, O. et al. Functional Implications of MicroRNAs in Crohn`s Disease Revealed by Integrating MicroRNA and Messenger RNA Expression Profiling. Int. J. Mol. Sci. 2017, 18, 1580 (International Journal of Molecular Sciences)
IJMS, Vol. 18, Pages 2119: Transforming Growth Factor-? Drives the Transendothelial Migration of Hepatocellular Carcinoma Cells (International Journal of Molecular Sciences)
 
 
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