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RSS FeedsCD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response (Cell Metabolism)

 
 

9 november 2017 17:31:42

 
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response (Cell Metabolism)
 


Chatterjee et al. show that intracellular NAD+ levels control the anti-tumor potential of hybrid Th1/17 cells through the NAD+-Sirt1-Foxo1 axis. Expression of the NADase CD38 inversely correlates with NAD+ levels and regulates anti-tumor T cell response. Genetic ablation or antibody-mediated targeting of CD38 on T cells improves tumor control.


 
130 viewsCategory: Cell Biology
 
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