Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses (Cell Reports)

Chen et al. demonstrate that synaptotagmin 7 at cerebellar inhibitory synapses functions as a Ca2+ sensor for asynchronous release, facilitation, and vesicle pool replenishment. This triple function of Syt7 ensures efficacy and frequency independence of inhibitory synaptic transmission.