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22 november 2017 17:35:31

 
Small-Molecule Kinase Downregulators (Cell Chemical Biology)
 


The strategy of rationally designing bivalent ligands that target kinases for proteasomal degradation is compared with recent serendipitous discoveries that several monovalent ATP site kinase inhibitors are also able to downregulate their cognate binding proteins. The therapeutic prospects and challenges facing small-molecule degrader modalities are discussed.


 
162 viewsCategory: Biology, Chemistry, Biochemistry
 
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