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RSS FeedsBasal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand (Cell Metabolism)

 
 

16 january 2018 23:31:52

 
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand (Cell Metabolism)
 


The Parkinson`s disease protein PINK1 is regarded as a master regulator of mitophagy. McWilliams et al. discover that endogenous PINK1 is dispensable for basal mitophagy in vivo. Furthermore, they define a rigorous framework to detect endogenous PINK1 protein in mouse tissues. This reveals the complex, context-dependent nature of mammalian mitophagy.


 
252 viewsCategory: Cell Biology
 
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