In Vivo Function of the Chaperonin TRiC in ?-Actin Folding during Sarcomere Assembly (Cell Reports)

TRiC-deficient zebrafish feature specific defects in sarcomere and neurite formation. Berger et al. demonstrate a role for TRiC as a multiprotein scaffold positioned at the sarcomere`s Z-disk, where it enhances the processing of skeletal muscle ?-actin. Accordingly, TRiC causes aggregation of myopathic ?-actin variants in nemaline myopathy.