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RSS FeedsViruses, Vol. 10, Pages 45: The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis (Viruses)

 
 

19 january 2018 01:30:27

 
Viruses, Vol. 10, Pages 45: The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis (Viruses)
 


Persistent infections with High Risk Human Papillomaviruses (HR-HPVs) are the main cause of cervical cancer development. The E6 and E7 oncoproteins of HR-HPVs are derived from a polycistronic pre-mRNA transcribed from an HPV early promoter. Through alternative splicing, this pre-mRNA produces a variety of E6 spliced transcripts termed E6*. In pre-malignant lesions and HPV-related cancers, different E6/E6* transcriptional patterns have been found, although they have not been clearly associated to cancer development. Moreover, there is a controversy about the participation of E6* proteins in cancer progression. This review addresses the regulation of E6 splicing and the different functions that have been found for E6* proteins, as well as their possible role in HPV-induced carcinogenesis.


 
229 viewsCategory: Epidemiology, Virology
 
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