Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw (Developmental Cell)

Barske et al. use combinatorial genetics in zebrafish to identify the Nr2f nuclear receptors as critical factors for specifying upper-jaw identity. Nr2fs selectively repress early cartilage formation in upper-jaw skeletal progenitors, thus creating morphological asymmetry with the lower but not upper jaw forming around a prominent cartilage template.