The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding (Cell Metabolism)

Benegiamo et al. identify a metabolic role for the nuclear RNA-binding protein NONO. Upon feeding, NONO binds to pre-mRNAs of genes involved in glucose and fat metabolism in the liver, regulating their rhythmic expression post-transcriptionally. NONO-deficient mice exhibit disruptions in this temporal regulation and shift from glucose storage to fat oxidation.