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RSS FeedsA Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence (Cell Reports)

 
 

16 april 2018 00:00:09

 
A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence (Cell Reports)
 




IDH-mutant lower-grade glioma glioblastoma often progresses to a more aggressive phenotype upon recurrence. de Souza et al. examines the intra-subtype heterogeneity of initial G-CIMP-high and use this information to identify predictive biomarkers for assessing the risk of recurrence and malignant transformation.


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101 viewsCategory: Cell Biology
 
Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation (Nature Cell Biology)
Author Correction: Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells (Nature Cell Biology)
 
 
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