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RSS FeedsA Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis (Cell Stem Cell)

 
 

11 may 2018 00:03:57

 
A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis (Cell Stem Cell)
 




Kang and colleagues identify linc1405 as a crucial regulator of cardiac differentiation via its interaction with Eomes. Linc1405 mediates an Eomes/WDR5/GCN5 regulatory complex at the Mesp1 enhancer, which coordinates Mesp1 expression and cardiac specification. They also show that linc1405 depletion results in impaired heart development and function in vivo.


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334 viewsCategory: Cell Biology
 
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