Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth (Developmental Cell)

Yeast is a natural food source for fruit flies, and accumulation of yeast particles in their midgut causes expansion of the gut tube. Li et al. show that such expansion triggers a mechanosensing mechanism leading to the relief of inhibition of Yorkie-mediated tissue growth by the upstream kinase Misshapen.