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RSS FeedsAn Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition (Cell Stem Cell)

 
 

25 may 2018 06:01:24

 
An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition (Cell Stem Cell)
 


Du et al. identify an intermediate `poised` pluripotent state characterized by specific mRNA and miRNA transcriptomes and the ability to contribute to mouse chimeras. ISY1-mediated miRNA regulation is necessary and sufficient for establishing poised pluripotency required for the naive-primed transition, providing an explanation for the early embryonic lethality of global miRNA deficiency.


 
136 viewsCategory: Cell Biology
 
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