Topology and Oligomerization of Mono- and Oligomeric Proteins Regulate Their Half-Lives in the Cell (Structure)

Mallik and Kundu show that native topology of monomeric proteins and sequestration of oligomeric proteins into macromolecular complexes influence their half-lives in the cell and during the course of evolution, presumably by burying ubiquitinoylation sites and disordered segments. The findings provide insights into the design principles of biological macromolecules.