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RSS FeedsA Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection (Cell Reports)

 
 

30 may 2018 18:00:09

 
A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection (Cell Reports)
 


Clark et al. show that a bacterial pathogen suppresses protective immunity through an inflammasome-dependent pathway. Stimulation of NLRP3-dependent interleukin (IL)-18 release licenses NK cells to produce the anti-inflammatory molecule IL-10. Batf3-dependent cells are vital for IL-18 release, which drives this regulatory natural killer cell activity.


 
94 viewsCategory: Cell Biology
 
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