A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells (Cell Host & Microbe)

Influenza A virus (IAV) infection is mediated by attachment of the viral hemagglutinin to sialic acid on the host cell surface. Fujioka et al. show that hemagglutinin binds to a voltage-dependent calcium channel in a sialylation-dependent manner and that inhibition of the channel resulted in suppression of IAV item and infection.