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RSS FeedsDirect Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks (Molecular Cell)

 
 

18 june 2018 14:00:19

 
Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks (Molecular Cell)
 


Dionne et al. uncover a mechanism through which receptor tyrosine kinases (RTKs) rapidly and reversibly terminate downstream signaling. The EPHA4 RTK directly phosphorylates an evolutionarily conserved Tyr present in NCK adaptor protein SRC homology (SH) 3 domains, which results in the collapse of signaling networks and abrogates their function.


 
46 viewsCategory: Molecular Biology, Cell Biology
 
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