Shaping Gene Expression by Landscaping Chromatin Architecture: Lessons from a Master (Molecular Cell)

In 1987, Davis, Weintraub, and Lassar reported that MyoD expression converted fibroblasts into myoblasts, opening the field of cell reprogramming. In this review, we use the lessons learned from MyoD to discuss how transcription factors access DNA to regulate gene expression by cooperatively shaping the chromatin landscape.