Global Maps of ProQ Binding In Vivo Reveal Target Recognition via RNA Structure and Stability Control at mRNA 3´ Ends (Molecular Cell)

Using CLIP-seq, Holmqvist et al. map transcriptome-wide interactions of the emerging global RNA-binding protein ProQ in Salmonella and E. coli. Their data suggest ProQ to target sRNAs and mRNA 3´ UTRs primarily through a structural code and to stabilize some mRNAs by counteracting 3´ exoribonuclease activity.