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18 june 2018 14:00:19

 
Cas4 Nucleases Define the PAM, Length, and Orientation of DNA Fragments Integrated at CRISPR Loci (Molecular Cell)
 


Shiimori et al. demonstrate integral roles of Cas4 nucleases in DNA acquisition for CRISPR-Cas immunity in P. furiosus. The concerted action of two different Cas4 nucleases is required for protospacer adjacent motif (PAM) definition, pre-spacer processing, and integration of DNA fragments at the CRISPR array in a functional orientation.


 
32 viewsCategory: Molecular Biology, Cell Biology
 
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