Sequence, Structure, and Context Preferences of Human RNA Binding Proteins (Molecular Cell)

Dominguez et al. describe in vitro binding specificities of 78 human RNA binding proteins (RBPs) to RNA sequences and structures. They find that many RBPs bind similar RNA motifs but differ in affinity for spaced `bipartite` motifs, flanking composition, and RNA structure, supporting the model that distinct motif occurrences are often discriminated based on sequence context.