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RSS FeedsStructural Basis for Transcript Elongation Control by NusG Family Universal Regulators (Cell)

 
 

18 june 2018 14:00:27

 
Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators (Cell)
 


NusG/Spt5 transcription elongation factors are the only transcription regulators conserved across all domains of life, assisting RNA polymerase elongation and linking the transcription complex to additional accessory factors genome wide. Cryo-electron microscopy structures of bacterial transcription complexes with NusG or its operon-specific paralog RfaH suggest NusG/RfaH inhibit backtrack pausing by stabilizing the upstream duplex DNA following the transcription bubble. RfaH further supresses pausing and termination by preventing RNA-hairpin induced swiveling, an RNA polymerase conformational change associated with pausing.


 
130 viewsCategory: Cell Biology, General
 
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