MyJournals Home  

RSS FeedsViruses, Vol. 10, Pages 327: The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity (Viruses)

 
 

18 june 2018 17:00:45

 
Viruses, Vol. 10, Pages 327: The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity (Viruses)
 


Phage therapy is based on a simple concept: the use of a virus (bacteriophage) that is capable of killing specific pathogenic bacteria to treat bacterial infections. Since the pioneering work of Félix d’Herelle, bacteriophages (phages) isolated in vitro have been shown to be of therapeutic value. Over decades of study, a large number of rather complex mechanisms that are used by phages to hijack bacterial resources and to produce their progeny have been deciphered. While these mechanisms have been identified and have been studied under optimal conditions in vitro, much less is known about the requirements for successful viral infections in relevant natural conditions. This is particularly true in the context of phage therapy. Here, we highlight the parameters affecting phage replication in both in vitro and in vivo environments, focusing, in particular, on the mammalian digestive tract. We propose avenues for increasing the knowledge-guided implementation of phages as therapeutic tools.


 
24 viewsCategory: Epidemiology, Virology
 
Viruses, Vol. 10, Pages 328: Whole Genome Analysis of Two Novel Type 2 Porcine Reproductive and Respiratory Syndrome Viruses with Complex Genome Recombination between Lineage 8, 3, and 1 Strains Identified in Southwestern China (Viruses)
Viruses, Vol. 10, Pages 326: NS1 Antigenemia and Viraemia Load: Potential Markers of Progression to Dengue Fatal Outcome? (Viruses)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Virology


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten