EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration (Developmental Cell)

Using a lineage-traced tumor model, Aiello et al. describe a program of epithelial-to-mesenchymal transition (EMT), conserved across several carcinomas, involving re-localization of epithelial proteins rather than transcriptional repression. This alternative program leads to a `partial EMT` phenotype that promotes collective tumor cell migration and formation of circulating tumor cell clusters.