Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia (Developmental Cell)

Parajuli et al. show that both genetic and pharmacological inhibition of Twist1 preserves muscle mass and extends lifespan in several mouse models of cancer cachexia, highlighting Twist1 as an attractive therapeutic target for attenuating muscle cachexia and associated morbidity and mortality in advanced cancer patients.