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RSS FeedsStructural Basis of Phosphatidic Acid Sensing by APH in Apicomplexan Parasites (Structure)

 
 

18 june 2018 19:00:28

 
Structural Basis of Phosphatidic Acid Sensing by APH in Apicomplexan Parasites (Structure)
 


High-resolution structures of a phosphatidic acid effector protein (APH) from both Plasmodium falciparum and Toxoplasma gondii parasites and its interaction with the lipid mediator unravel a new class of PH domain that initiates microneme-plasma membrane fusion by inserting and clustering phosphatidic acid within membranes.


 
96 viewsCategory: Biochemistry
 
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