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RSS FeedsBiophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747 (Structure)

 
 

18 june 2018 19:00:28

 
Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747 (Structure)
 


Rv1747, a putative transporter of Mtb envelope components, has two cytoplasmic phosphothreonine-binding FHA domains joined by a disordered linker with two phospho-acceptor threonines. Heinkel et al. showed that both FHA domains bind either linker phosphothreonine intra- and intermolecularly with differing affinities. This could enable tunable Rv1747 regulation through phosphorylation-dependent oligomerization.


 
99 viewsCategory: Biochemistry
 
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