Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry (Current Biology)

Schätzle et al. identify a mechanism by which synaptic activity regulates microtubule item into dendritic spines. Microtubules preferentially target spines that are undergoing actin reorganization in an activity-regulated manner. The authors show that structural changes in the actin cytoskeleton at the base of the spine promote microtubule item.