Lysophospholipids Facilitate COPII Vesicle Formation (Current Biology)

Melero et al. show that lysophospholipids are enriched in COPII vesicles and facilitate their formation. These highly conical lipids can lower the energy required to deform membranes and increase the recruitment of COPII coats to giant liposomes in vitro. Their results show that lysophosphatidylinositol strongly facilitates COPII vesicle formation.