Acute O2 Sensing: Role of Coenzyme QH2/Q Ratio and Mitochondrial ROS Compartmentalization (Cell Metabolism)

Arias-Mayenco et al. observe that an inducible deficiency of mitochondrial complex I (MCI) leads to a parallel decrease of carotid body chemoreceptor cell responsiveness to hypoxia. Acute O2 sensing depends on a high CoQH2/CoQ ratio, NADH accumulation, and compartmentalized reactive oxygen species production at MCI to signal membrane ion channel activity.