MyJournals Home  

RSS FeedsDeficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice [Research Articles] (Journal of Lipid Research)

 
 

6 august 2018 11:40:46

 
Deficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice [Research Articles] (Journal of Lipid Research)
 




GM3, a precursor for synthesis of a- and b-series gangliosides, is elevated in adipocytes of obese model animals and in sera of obese human patients with type 2 diabetes and/or dyslipidemia. GM3 synthase (GM3S)-KO C57BL/6 mice display enhanced insulin sensitivity and reduced development of high-fat diet-induced insulin resistance. However, the pathophysiological roles of GM3 and related gangliosides in the central control of feeding and metabolism remain unclear. We found that a mouse model (KKAy GM3S KO) generated by KO of the GM3S gene in the yellow obese strain, KKAy, displayed significant amelioration of obese phenotype. Whereas KKAy mice were hyperphagic and developed severe obesity, KKAy GM3S KO mice had significantly lower body weight and food intake, and greater glucose and insulin tolerance. The hypothalamic response to intraperitoneal administration of leptin was greatly reduced in KKAy mice, but was retained in KKAy GM3S KO mice. In studies of a cultured mouse hypothalamic neuronal cell line, enhanced leptin-dependent phosphorylation of ERK was observed in GM3S-deficient cells. Furthermore, KKAy GM3S KO mice did show altered coat color, suggesting that GM3S is also involved in melanocortin signaling. Our findings, taken together, indicate that GM3-related gangliosides play key roles in leptin and melanocortin signaling.


Del.icio.us Digg Facebook Google StumbleUpon Twitter
 
70 viewsCategory: Cell Biology, Molecular Biology
 
Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite [Research Articles] (Journal of Lipid Research)
Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature [Research Articles] (Journal of Lipid Research)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Molecular Biology

Use these buttons to bookmark us:
Del.icio.us Digg Facebook Google StumbleUpon Twitter


Valid HTML 4.01 Transitional
Copyright © 2008 - 2018 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn