Cryo-EM for Small Molecules Discovery, Design, Understanding, and Application (Cell Chemical Biology)

Scapin et al., present their perspective of the possible application of cryoelectron microscopy (cryo-EM) to structure-based drug design (SBDD) approach. They discuss SBDD requirements, cryo-EM current state, and the challenges that need to be overcome for this technique to reach its full potential in facilitating the process of drug discovery.