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17 august 2018 06:00:08

 
Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death (Cell Chemical Biology)
 


Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly conserved bacterial ClpP protease. We identified ADEP analogs that are potent dysregulators of the human mitochondrial ClpP (HsClpP). The compounds were found to cause apoptotic cell death. The ADEP-HsClpP co-crystal structure revealed, unexpectedly, HsClpP in the compact conformation.


 
87 viewsCategory: Biology, Chemistry, Biochemistry
 
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