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RSS FeedsConventional and Neo-Antigenic Peptides Presented by ? Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors (Cell Metabolism)

 
 

24 september 2018 17:00:56

 
Conventional and Neo-Antigenic Peptides Presented by ? Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors (Cell Metabolism)
 


Mallone et al. use peptidomics and transcriptomics to identify the epitopes presented by ? cells that trigger type 1 diabetes (T1D) autoimmunity. Multiple pathways, including conventional processing and mRNA and peptide splicing, are involved in epitope generation and presentation; these epitopes are selectively recognized by pancreas-infiltrating CD8+ T lymphocytes in T1D patients.


 
61 viewsCategory: Cell Biology
 
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